CAS Number: 13721-39-6
Linear Formula: Na3VO4
Molecular Weight: 183.91
EC Number: 237-287-9
MDL Number: MFCD00003511
PubChem Substance ID: 24899708
Biochem/physiol Actions
Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25
Packaging
10, 50, 250 g in poly bottle
Application
Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27
Assay: ≥90% (titration)
Color: white to off-white
MP: 850-866 °C(lit.)
Solubility: H2O: soluble