Synonyms: 7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, hydrate (2:3); DU 6859 sesquihydrate; DU 6859a sesquihydrate; DU-6859 sesquihydrate; DU-6859a sesquihydrate; DU6859 sesquihydrate; DU6859a sesquihydrate
Molecular Formula: C19H18ClF2N3O3·1.5H2O
Molecular Weight: 436.84
Linear Structural Formula: C19H18ClF2N3O3·1.5H2O
MDL Number: MFCD00903720
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Sitafloxacin (DU-6859 or DU-6859a) is an orally active, fourth generation fluoroquinolone that exhibits broad-spectrum antibiotic activity against many Gram-positive, Gram-negative and anaerobic clinical isolates, including strains resistant to other fluoroquinolones, via dual inhibitory activity against bacterial DNA gyrase and topoisomerase IV (IC50 = 1.16 and 1.88 mug/mL against S. pneumoniae gyrA/B and parC/E, respectively). Sitafloxacin is active against methicillin-resistant staphylococci, Streptococcus pneumoniae and other streptococci with reduced susceptibility to levofloxacin and other quinolones and enterococci. Sitafloxacin also exhibits activity against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa as well as some activity against quinolone-resistant strains and Acinetobacter baumannii. Sitafloxacin in vitro activity against anaerobes is comparable to imipenem and metronidazole.