Interferon gamma (IFNgamma) is a dimerized soluble cytokine that is the only member of the type II class of interferons. IFNgamma is secreted by T helper cells (specifically, Th1 cells), cytotoxic T cells (TC cells) and Natural killer (NK) cells. When combined with other inflammatory cytokines, evaluating the levels of IFNgamma can be used as a diagnostic tool in patients with breast cancer or benign prostatic hyperplasia. A recent study evaluated the effect of a cancer vaccine given to patients with colorectal cancer, on the levels of plasma pro-inflammatory cytokines (including IFN-gamma). The study concluded that patients achieving stable disease showed increasing levels of plasma inflammatory cytokines.
Synonyms: IFNgamma; IFN-gamma; Immune interferon; Immuneinterferon
Purity: >=98% (SDS-PAGE)
Storage: -20C
Biochem Physiol Actions: SILu(TM)Prot IFNG is a recombinant, stable isotope-labeled human IFNG which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of IFNG in mass-spectrometry. SILu Prot IFNG is a homodimer consisting of 138 amino acids, with a calculated molecular mass of 17 kDa.
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