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MilliporeSigma

S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt, >=80% (HPLC), >=80% (spectrophotometric assay)

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S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt, >=80% (HPLC), >=80% (spectrophotometric assay)

Synonyms: AdoMet; SAM p-toluenesulfonate salt

CAS Number: 52248-03-0

Formula: C15H23N6O5S · C7H7O3S · xC7H8O3S

Formula Weight: 570.64 (free base basis)

Linear Formula: C15H23N6O5S · C7H7O3S · xC7H8O3S

Purity: >=80% (HPLC); >=80% (spectrophotometric assay)

Storage: -20C

UNSPSC Code: 12352200

Biochem/physiol Actions: Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Biochem/physiol Actions: S-(5'-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

RIDADR: NONH for all modes of transport

WGK Germany: 3

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Thomas No.
C971C20
Mfr. No.
A2408-100MG
Description
SIGMA S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt, 100 mg
CAS Number
52248-03-0
list price/quantitytotal
$0.00
Thomas No.
C971C19
Mfr. No.
A2408-25MG
Description
SIGMA S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt, 25 mg
CAS Number
52248-03-0
list price/quantitytotal
$0.00
Thomas No.
C971C21
Mfr. No.
A2408-500MG
Description
SIGMA S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt, 500 mg
CAS Number
52248-03-0
list price/quantitytotal
$0.00
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