PTP-beta human, >=90%, recombinant, expressed in E. coli K12, GST-tagged, buffered aqueous glycerol solution, >=50,000 units/mg protein

Synonyms: Protein Tyrosine Phosphatase-beta

MDL No.: MFCD02688688

Purity: >=90%

Storage: -70C

UNSPSC Code: 12352200

General description: Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.

Biochem/physiol Actions: Dephosphorylates tyrosine proteins.

Physical form: solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol

Unit Definition: One unit of PTP-beta will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 C.