Synonyms: PPA2A1
MDL No.: MFCD00241719
Purity: >=90% (SDS-PAGE)
Storage: -70C
UNSPSC Code: 12352204
Application: Protein Phosphatase 2A1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dis-regulation in cancer. The enzyme is involved in regulating numerous cellular processes and is used to study cell cycle, growth, and differentiation. Sigma protein phosphatase 2A1 has been used to treat human fibroblast cells prior to Western Blot analysis.
Biochem/physiol Actions: Protein Phosphatase 2A1 is a trimer consisting of the A, B, and C subunits of the PP2A family. It has a total molecular weight of 192 kDa. Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with mictotubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity.
Physical form: Solution in 50 mM Tris-HCl, pH 7.0, containing 14 mM 2-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol
Unit Definition: One unit will release 1.0 nanomole of phosphate from 32P-labeled phosphorylase A per minute at pH 7.0 at 30 C.
RIDADR: NONH for all modes of transport
WGK Germany: 1