Prostaglandin F Synthase human, recombinant, expressed in E. coli, >=90% (SDS-PAGE)

Synonyms: 17-beta-hydroxysteroid dehydrogenase type 5; AKR1C3; aldo-keto reductase family 1 member C3; indanol dehydrogenase

CAS Number: 55976-95-9

Purity: >=90% (SDS-PAGE)

Storage: -70C

Enzyme Commission (EC) Number: 1.1.1.188  ( BRENDA | IUBMB )

UNSPSC Code: 12352204

Application: Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

Biochem/physiol Actions: PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .

Unit Definition: One unit is defined as the amount of enzyme required to produce 1 mumol of NADP per minute at 37C in 50 mM KPO4 pH 7.2 containing 250 muM NADPH and 25 muM 9,10-phenanthrenequinone