Synonym(s): (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid; Dinoprostone; PGE2
Formula: C20H32O5
Formula Weight: 352.47
CAS No.: 363-24-6
Application: For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
Physical form: powder -20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Storage: −20°C
Beilstein Registry Number: 4709356
EC No.: 206-656-6
Biochem/physiol Actions: Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.1
Empirical Formula (Hill Notation): C9H10O2