Synonym(s): PDGF-AB
Purity: ≥97% (SDS-PAGE and N-terminal analysis)
Physical form: Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid.
Analysis Note: The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.
Other Notes: Heterodimer of the A and B chains of PDGF disulfide linked.
Storage: −20°C
Biochem/physiol Actions: Cellular actions of PDGF include chemoattraction and activation of neutrophils, monocytes, and fibroblasts. PDGF appears to play a crucial role in the cellular response to tissue injury and is critically involved in the pathological progression of atherosclerosis.
Empirical Formula (Hill Notation): C14H21NO4