Anti-PMP70 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma 70-18 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. The 70 kDa peroxisomal membrane protein (PMP70), also designated PXMP1 and ABCD3 or ABD3, is one of the major components of peroxisomal membranes. PMP70 belongs to the ALD subfamily of the ATP binding cassette (ABC) transporter superfamily. It is a half-size ABC integral membrane protein consisting of 6 transmembrane domains and one ATP-binding domain.
Synonyms: Anti- ZWS2; ZELLWEGER SYNDROME 2; Anti-70 kDa Peroxisomal membrane Protein; Anti-ABCD3; Anti-ATP-binding cassette, sub-family D (ALD), member 3; Anti-PXMP1
MDL Number: MFCD01865555
Storage: -20C
Application: Anti-PMP70 antibody, Mouse monoclonal has been used in immunoblotting and immunofluorescence.
Biochem Physiol Actions: The 70 kDa peroxisomal membrane protein (PMP70) participates in the metabolic transport of long and very long fatty acids into peroxisomes. It forms a stable complex with the adrenoleukodystrophy protein, adrenoleukodystrophy protein (ALDP), and several other peroxisomal proteins. Mutations in the PMP70 (PXMP1) gene may cause a subset of Zellweger syndrome-2, an autosomal recessive disorder that is manifested by defective import mechanisms for peroxisomal matrix enzymes.