Monoclonal Anti-Phosphoserine antibody produced in mouse, clone PSR-45, purified immunoglobulin, buffered aqueous solution

Synonyms: Monoclonal Anti-Phosphoserine; Phospho Ser; Phospho serine; Phospho-Ser; Phospho-serine

Storage: -20C

Application: The antibody has been used for the detection of some phosphoserine containing proteins using immunoblotting and dot blotting.

Biochem Physiol Actions: Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins.