MDL No.: MFCD04040943
Storage: -20C
UNSPSC Code: 12352203
General description: Cateninβ is a multifunctional protein, coded by CTNNB1 (cateninβ 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1.
Application: Monoclonal Anti-phospho-beta-Catenin (pSer33) antibody produced in mouse is suitable for microarray and western blotting at a concentration of 5mug/mL using total cell extracts of cultured HEK-293T cells treated with MG132.
Biochem/physiol Actions: Mutations in β-catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing BCR-ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. CTNNB1 plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway.
Biochem/physiol Actions: Catenin (cadherin-associated protein), β 1 (88kDa) protein is encoded by CTNNB1 gene in humans. It is also called as β-catenin. It is a dual function protein that regulates the coordination of cell-cell adhesion and gene transcription. Human β-catenin is located at band p21 on chromosome 3.
Immunogen: synthetic phosphopeptide corresponding to the region that contains serine 33 of human beta-catenin.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.