Synonyms: Anti-TRP53; Anti-Transformation-related protein 53
MDL No.: MFCD00164709
Storage: -20C
UNSPSC Code: 12352203
General description: p53 is a transcription factor that regulates several critical cellular functions such as DNA repair, apoptosis, and cell cycle arrest. p53 primarily functions as a tumor suppressor and inactivates apoptosis inhibitors such as survivin, MCL-1 and BCL-2. Mutations in p53 gene occur most commonly in a wide range of human cancers. Thus, analysis of p53 function has important implications in cancer pathogenesis and therapy . Monoclonal Anti-p53 antibody specifically reacts with p53 in humans.
Application: Monoclonal Anti-p53 antibody is suitable for use in various immunological techniques such as immunocytochemistry, immunoprecipitation, immunohistochemistry, indirect ELISA, immunoblot (approx. 53 kDa) and western blot (0.1-0.2 mug/mL using human A431).
Immunogen: recombinant human wild type p53.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3