Synonyms: Anti-OB
CAS Number: 93952-18-2
MDL No.: MFCD00803408
Storage: -20C
UNSPSC Code: 12352203
General description: Leptin is a hormone secreted by adipocytes and regulates energy homeostasis, inflammation and neuroendocrine processes, synaptic formation and memory condensation. The physiological effects of leptin are mediated by leptin receptors, ObR and LepR. The receptors are present in brain, lungs, kidneys, liver and adipose tissue. Leptin is the key regulator of obesity and acts directly on neuronal networks to regulate feeding, metabolism, gastric mobility and energy homeostasis. The pathways that mediate the effect of leptin are JAK/STAT, PI3K and JNK. Deficiency of leptin may be a congenital condition and results in thyroid axis abnormalities.. Monoclonal Anti-Leptin reacts specifically with human leptin. A weak cross reactivity with mouse leptin is observed in radioimmunoassay.
Application: Monoclonal Anti-Leptin antibody may be used for immunoblotting at a working dilution of 1:1000. It has been used for detection by immunoblotting in human ovarian epithelial carcinoma cell line, OVCAR-3. The antibody is suitable for radioimmunoassay and ELISA.
Immunogen: recombinant human leptin.
Specificity: The antibody reacts specifically with human leptin. By RIA, weak cross-reactivity has been observed with recombinant mouse leptin.
RIDADR: NONH for all modes of transport
WGK Germany: 3