Synonyms: L1CAM Antibody - Anti-L1CAM antibody, Mouse monoclonal; L1Cam Antibody; Anti-CAML1; Anti-L1 Cell Adhesion Molecule; Anti-MIC5; Anti-Neural Cell Adhesion Molecule L1
MDL No.: MFCD01864727
Storage: -20C
UNSPSC Code: 12352203
General description: The gene L1CAM (L1 cell adhesion molecule) encodes a member of the immunoglobulin supergene family. The encoded protein contains a cytoplasmic intracellular domain, one single-pass transmembrane region and an extracellular domain containing six immunoglobulin- (Ig) and five fibronectin (Fn) III-like motifs. The gene is mapped to human chromosome Xq28. It contains 29 exons that encode a protein of 1257 amino acids containing a 19 amino acid signal peptide and a functional L1 protein of 1238 amino acids. It is mainly expressed in the nervous system.
Application: Anti-L1CAM antibody has been used in immunohistochemistry.
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)Western Blotting (1 paper)
Biochem/physiol Actions: The gene L1CAM (L1 cell adhesion molecule) encodes a glycoprotein that functions in axon growth during development and axon bundling. It interacts with Schwann cells and axons, and mediates neuronal cell migration, and neuronal cell survival. Overexpression of this protein is associated with tumor progression. It has been found to mediate therapeutic resistance in ovarian and pancreatic cancer cells.
Immunogen: L1CAM from human fetal brain.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3