Monoclonal Anti-Human IgG2-FITC antibody produced in mouse, clone HP-6014, purified immunoglobulin, buffered aqueous solution

Synonyms: Monoclonal Anti-Human IgG2

Storage: -20C

UNSPSC Code: 12352203

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General description: Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. It consists of a γ heavy chain in the constant (C) region. The monomeric 150kDa structure of IgG constitutes two identical heavy chains and two identical light chains with molecular weight of 50kDa and 25kDa, respectively. The primary structure of this antibody also contains disulfide bonds involved in linking the two heavy chains, linking the heavy and light chains and residues inside the chains. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3, and IgG4 with different heavy chains, named γ1, γ2, γ3, and γ4, respectively. Limited digestion using papain cleaves the antibody into three fragments, two of which are identical and contain the antigen-binding activity. They are known as fragment antigen binding (Fab) fragments. These fragments contain light chains paired with the VH and CH1 domains of the heavy chains.

Application: Monoclonal Anti-Human IgG2-FITC antibody produced in mouse has been used in immunohistochemistry.

Physical form: Solution in 0.01 M phosphate buffered saline, pH8, containing 1% inactivated bovine serum albumin and 15 mM sodium azide.

Specificity: The antibody is specific for human IgG2 and is non-reactive with other IgG subclasses. This clone has been singled out as the most widely applicable IgG2 specific monoclonal antibody by the IUIS/WHO study.