Synonyms: Anti-KIAA1081
MDL No.: MFCD08705584
Storage: -20C
UNSPSC Code: 12352203
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Application: Monoclonal Anti-ELKS antibody produced in mouse is suitable for the following applications:. Immunocytochemistry. Immunoprecipitation and staining. Microarray. Western blotting at a concentration of 0.5-1μg/mL using HeLa cell extract
Biochem/physiol Actions: ELKS/RAB6-interacting/CAST family member 1 is a protein encoded by the ERC1 gene in humans. It encodes for a synaptic factor and is found in the smallest region of overlap. ERC1 encodes a regulator of neurotransmitter release and acts as the best gene candidate contributing to this phenotype as well as to the autism spectrum disorder ASD. ERC1a (an isoform of ERC1) is associated with other proteins for effective migration and tumor cell invasion by stabilizing the activity at the cell front. Depletion of any of the associated protein negatively affects invasion, migration on extracellular matrix, lamellipodial persistence and the internalization of active integrin β1 receptors needed for adhesion turnover at the front of the cell.
Immunogen: synthetic peptide corresponding to amino acids 21-40 of human ELKS.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3