Synonyms: Anti-ER degradation enhancer, mannosidase alpha-like 3
Storage: -20C
UNSPSC Code: 12352203
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General description: Three EDEM homologs, EDEM1, EDEM2 and EDEM3 have been identified, which are transcriptionally upregulated upon ER stress by the activated IRE1/Xbp-1 branch.
Application: Monoclonal Anti-EDEM3 antibody produced in mouse is suitable for immunoblotting at a working concentration of 1-2mug/mL using a whole extract of mouse 3T3 or rat NRK cells.
Biochem/physiol Actions: EDEM3 (ER degradation enhancer, mannosidase alpha-like 3), a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation (ERAD) and mannose trimming. EDEM3 accelerates ERAD of misfolded glycoproteins as well, but in ontrast to EDEM1, it greatly stimulates mannosidase trimming in vivo.
Immunogen: synthetic peptide corresponding to amino acids 869-882 of human EDEM3, conjugated to KLH. The corresponding sequence is identical in mouse and rat EDEM3.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.