MDL No.: MFCD01633297
Storage: -20C
UNSPSC Code: 12352203
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General description: DHP receptor is composed of at least four subunits. The alpha1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated Na+ channel. The alpha2 subunit is a large glycoprotein and the other 2 subunits are termed beta and gamma.
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunofluorescence (1 paper)
Application: Monoclonal Anti-Dihydropyridine Receptor (α1 Subunit) antibody produced in mouse is suitable for immunoprecipitation, immunohistochemistry at a working dilution of 1:500 and immunoblotting at 1:2000. It was used for the detection and localization of DHPR-1α by western blotting in skeletal muscle tissue sections of mice in a study. The antibody may be used to inhibit the DHP-sensitive calcium current in BC3H1 mouse muscle cells.
Biochem/physiol Actions: The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type Ca2+ channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling.
Immunogen: rabbit muscle transverse tubule dihydropyridine (DHP) receptors.
Physical form: Solution in phosphate buffered saline containing 0.05% sodium azide.
Specificity: Reacts specifically with the alpha1 subunit of the DHP receptor. May be used to inhibit the DHP-sensitive calcium current in BC3H1 mouse muscle cells. By immunohistochemistry, double rows of discrete punctate staining represent pairs of triads on the opposing sides of the Z-lines.
RIDADR: NONH for all modes of transport
WGK Germany: nwg