Synonyms: Anti-Drosophila Epidermal Growth Factor Receptor; Anti-dEGFR
MDL No.: MFCD08705583
Storage: -20C
UNSPSC Code: 12352203
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Application: Suitable for the following:. Immunohistochemistry. Indirect ELISA. Western blotting at a concentration of 0.25-0.5mug/mL using recombinant protein representing amino acids 299-359 of the Drosophila EGFR extracellular domain
Biochem/physiol Actions: The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and belongs to erbB family of tyrosine kinase receptors. It binds to its cognate ligands that lead to autophosphorylation of receptor tyrosine kinase and subsequent activation of signal transduction pathways that are involved in regulating cellular proliferation, differentiation and survival. EGFR is overexpressed in tumor cell lines and is associated with poor prognosis leading to decreased survival. Its activation also plays a role in resistance to chemotherapy and radiation treatment in tumor cells. EGFR tyrosine kinase inhibitors (TKIs) may act as a new treatment option for advanced lung adenocarcinoma. Its ligands function in the Drosophila CNS and maintains glial survival. Drosophila EGF receptor plays a critical role during the development of Drosophila retina.
Immunogen: recombinant extracellular fragment of Drosophila EGFR (amino acids 299-359).
Physical form: Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 3