Monoclonal Anti-Death Associated Protein Kinase antibody produced in mouse, clone DAPK-55, ascites fluid

Synonyms: Anti-DAP Kinase

MDL No.: MFCD00282220

Storage: -20C

UNSPSC Code: 12352203

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General description: The gene is widely expressed in many tissues of embryonic and adult origin and gives rise to a single 6.3 Kb mRNA transcript. The protein consists of 1423 amino acids (160 kDa) and belongs to a family of calmodulin-dependent protein kinases. It contains 8 ankyrin repeats and 2 potential P-loop motifs apart from the kinase domain and the calmodulin regulatory domain.

Application: Monoclonal Anti-Death Associated Protein Kinase antibody produced in mouse is suitable for immunoprecipitation, microarray and western blotting at a working dilution of 1:250 using COS-7 cell extract. It may be used for the detection and quantification of kinase activity of DAP Kinase using various immunochemical assays such as immunoblot and immunoprecipitation.

Biochem/physiol Actions: DAP-kinase is a novel, structurally unique, human serine/threonine kinase identified as a positive mediator of interferon-γ-induced programmed cell death. It has an intrinsic kinase activity towards itself that is regulated by calmodulin and calcium.

Immunogen: recombinant human DAP kinase expressed in bacteria.