MDL No.: MFCD00162250
Storage: -20C
UNSPSC Code: 12352203
Application: Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse is suitable for the following applications:. immunohistochemistry (using formalin-fixed, paraffin-embedded sections). indirect immunofluorescence: at a working dilution of 1:100 using formalin-fixed, paraffin-embedded sections of human tissue. microarray
Biochem/physiol Actions: Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.
Immunogen: keratin from the bovine mammary gland epithelial cell line BMGE.
Specificity: The antibody reacts with a wide variety of simple epithelia (gastrointestinal, respiratory, urinary, liver, and glandular) but does not react with most stratified squamous epithelium (esophagus, epidermis) or non-epithelial cells.
RIDADR: NONH for all modes of transport
WGK Germany: 2
R Codes: 21/22
S Codes: 36/37-60
IOD Codes: Xn