MDL No.: MFCD03792415
Storage: -20C
UNSPSC Code: 12352203
General description: The description of specific intranuclear structures known today as Cajal bodies was first published in 1903 by the neuro-cytologist Ramon-gamma-Cajal who discovered that neurons contained spherical structures of around 0.5 mum in diameter that were often associated with nucleoli, nucleolar accessory bodies. Later, the same bodies were called coiled bodies since when these structures were viewed by electron microscopy, they resembled a tangle of coiled threads. It was found that patients with auto-antibodies against coiled bodies recognize a protein of 80 kDa termed p80-coilin. Using these antibodies, coiled bodies were identified in plants, flies, frogs, birds, and mammals.
Application: Monoclonal Anti-Coilin reacts with an epitope located between amino acids 363 and 481 of human coilin. It may be used in immunoblotting (approx. 80 kDa), immunocytochemistry, and cell microinjection.
Immunogen: C-terminal (389 amino acids) human coilin
Physical form: Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Specificity: The antibody recognizes the C-terminal region of human coilin and does not recognize mouse coilin.