The ß-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes ß-secretase (BACE1) and ?-secretase to produce ß-amyloid (Aß) peptides with the Aß1-42 and the Aß1-40 forms being the most prevalent. Secreted Aß peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aß leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer's disease (AD).
Synonyms: Anti-Abeta
MDL Number: MFCD00803867
Storage: -20C
Application: Mouse Monoclonal Anti-ß-Amyloid antibody has been used for western blot assays. The product can also be used for immunohistochemistry, immunoprecipitation, indirect ELISA and microarray studies.
Biochem Physiol Actions: ß-amyloid gene acts as the substrate of insulin-degrading enzyme (IDE). It plays a major role in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2).