Synonyms: Monoclonal Anti-Aurora-A Kinase; Monoclonal Anti-Aurora-A Kinase antibody produced in mouse; Anti-ARK-1; Anti-AURORA2; Anti-Aurora-related kinase 1; Anti-BTAK; Anti-STK15; Anti-STK6; Anti-Serine/threonine protein kinase 15
MDL No.: MFCD06411780
Storage: -20C
UNSPSC Code: 12352203
General description: Aurora-A (Aur-A) kinase is a serine threonine kinase that regulates cell division. Elevated levels of Aur-A have been associated with inhibition of apoptosis, and evasion of spindle assembly checkpoints. Aur-A may also be used as a prognostic marker for nasopharyngeal cancers in humans . Monoclonal Anti-Aurora-A Kinase antibody is specific for Aurora-A Kinase in humans and mice.
Application: Monoclonal Anti-Aurora-A Kinase antibody is suitable for use in immunocytochemistry, immunoprecipitation, immunoblot, indirect ELISA and western blot (0.25-0.5 mug/mL using HeLa total cell extract). The antibody product does not inhibit kinase activity of Aurora-A kinase, hence the product can be used to measure the in vivo aurora-A kinase activity after immunoprecipitation.
Application: Aurora A kinase is required for proper mitotic spindle organization and localizes to centrosomes at sites of microtubule nucleation in Hela cells. Aurora A kinase is immunoprecipitated from cytoskeletal extracts using monoclonal anti-Aurora A kinase antibody. Aurora B and C are not found expressed on centromeres.
Immunogen: recombinant human Aurora-A kinase.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
RIDADR: NONH for all modes of transport
WGK Germany: 3