Monoclonal Anti-Angiopoietin-1 antibody produced in mouse, clone 171718, purified immunoglobulin

Synonyms: Anti-ANG-1

MDL No.: MFCD06798694

Storage: -20C

UNSPSC Code: 51111800

General description: Angiopoietins are growth factors vital for vascular differentiation during normal development. There are four angiopoietins discovered that bind to receptor tyrosine kinases Tie2. Angiopoietin-1 (ANG-1) is a potent pro-angiogenic factor that works by recruits mural cells for endothelial tubule formation and vessel maturation. ANG-1 acts along with VEGF in enhance angiogenesis and increase vascular branching. ANG-1 also affects the inflammatory process and inhibits the capillary transmigration of leukocytes on TNF-α stimulation. Sonic hedgehog, a secreted growth factor, reportedly upregulates the expression of ANG-1. Overexpression of angiopoietins has been observed in a variety of malignancies including neuroblastoma, glioblastoma and lung cancers. While ANG-2 increases the metastasis and angiogenesis of the tumors, ANG-1 inhibits tumor angiogenesis Anti-Angiopoietin-1 detects recombinant human angiopoietin-1. The antibody shows no cross-reactivity with recombinant human angiopoietin-2, recombinant human angiopoietin-4, recombinant mouse angiopoietin-like 3, and recombinant human cornea-derived transcript 6 (CDT-6).

General description: Angiopoietin 1 is an endothelial cell-specific protein that is a ligand for the TIE2 tyrosine receptor. It is required for mature blood vessel formation.

Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

Immunogen: purified, NSO-derived, recombinant human ANG-1.

Physical form: Lyophilized from a 0.2 mum filtered solution in phosphate buffered saline with 5% trehalose