Formula: C15H18N4O5
Formula Weight: 334.33
CAS No.: 50-07-7
Application: Mitomycin C is used to generate mitotically inactive feeder cells used in cell culture systems, such as mitotically inactive fibroblast used in embryonic stem cell (ESC) systems.
General description: Mitomycin C is an anti-neoplastic antibiotic, DNA inter-strand, cross-linking, alkylating agent that targets guanine nucleoside in the sequence 5′CpG-3′. It produces oxygen radicals and is preferentially toxic to hypoxic cells.
Other Notes: Vial contains 2 mg mitomycin C and 48 mg NaCl.
Storage: 2-8°C
Beilstein Registry Number: 7231816
Biochem/physiol Actions: Inhibitor of DNA synthesis, nuclear division, and cancer cells. Antibacterial to gram positive, gram negative, acid-fast bacilli.
Empirical Formula (Hill Notation): C5H6S