SIGMA L-Glutathione reduced, cell culture tested, BioReagent, =98.0%, powder

Synonyms: γ-L-Glutamyl-L-cysteinyl-glycine; GSH

Formula: H₂NCH(CO₂H)CH₂CH₂CONHCH(CH₂SH)CONHCH₂CO₂H

Formula Weight: 307.32

CAS No.: 70-18-8

Purity: ≥98.0%

Storage Temperature: 2-8°C

Application: May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Amino Acid Sequence: γ-Glu-Cys-Gly

Biochem/physiol Actions: Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.