Synonyms: HSPG
MDL No.: MFCD00283416
Storage: -20C
UNSPSC Code: 12352200
Application: Heparan Sulfate promotes the attachment of cells in culture and induces high affinity binding of FGF-basic to cells deficient in heparin sulfate and soluble FGF receptors at a concentration of 10-100 ng/mL.
Biochem/physiol Actions: This is a multifunctional molecule. As a component of the extracellular matrix that binds to fibroblast growth factors, vascular endothelial growth factor and vascular endothelial growth factor receptors. It also acts as a docking molecule for matrilysin and other matrix metalloproteinases.
Components: Heparan sulfate proteoglycan is a large biomolecule composed of a core protein covalently bound to heparin sulfate chains that is an integral part of the basement membrane. The number of polysaccharide chains and the size of the core protein are variable according to the source.
Preparation Note: This product is isolated from the basement membrane of Engelbreth-Holm-Swarm mouse sarcoma in a solution containing 50 mM Tris HCl at pH 7.4, 150 mM NaCl, 1 mM EDTA, and 0.1 mM PMSF.
RIDADR: NONH for all modes of transport
WGK Germany: 3