Synonyms: Epidermal Growth Factor human; EGF
CAS Number: 62253-63-8
MDL No.: MFCD00132565
Purity: >97% (SDS-PAGE)
Storage: -20C
UNSPSC Code: 12352200
General description: Epidermal Growth Factor (EGF) is a small mitogenic polypeptide (>=6 kDa), which is present in many mammalian species and is distributed throughout a wide number of tissues and body fluids.1 Human EGF is identical to beta-urogastrone, a polypeptide which was recognized and isolated on the basis of its ability to inhibit gastric acid secretion.2 EGF is a member of a growth factor family, which is characterized by the presence of 6 conserved cysteine motifs that form three disulfide bonds. The location of 3 intrachain disulfide bonds in recombinant human EGF is identical to that of mouse EGF.3 EGF is homologous to a sequence contained in a 19 kDa protein of vaccinia virus,5 which appears to utilize the EGF receptor to gain entry into cells.6 EGF is mitogenic for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, and SV40-3T3 cells.1
RIDADR: NONH for all modes of transport
WGK Germany: 2