Synonyms: (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1alpha,3beta-diol; (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol; 1alpha-Hydroxyergocalciferol; 1alpha-Hydroxyvitamin D2; 1alpha-OHD2; 1-alpha-Hydroxyvitamin D2; 1-Hydroxyergocalciferol; TSA 840
CAS Number: 54573-75-0
Formula: C28H44O2
Formula Weight: 412.65
Linear Formula: C28H44O2
MDL No.: MFCD00871065
Purity: >=98% (HPLC)
Storage: -20C
UNSPSC Code: 12352200
Biochem/physiol Actions: Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1alpha, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.
Biochem/physiol Actions: Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1alpha,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
R Codes: 28
S Codes: 28-36/37-45
IOD Codes: T+
Symbol: GHS06
Signal Word: Danger
Hazard Statements: H300
Precautionary statements: P264-P301 + P310