Synonyms: DPP7; Quiescent cell proline dipeptidase
Activity: activity: >=1,500 units/mug protein; activity: >=1500 units/mug protein
Storage: -70C
Enzyme Commission (EC) Number: 3.4.14.-
UNSPSC Code: 12352204
Application: Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes . DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research .
Biochem/physiol Actions: DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 . DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.
Physical form: Supplied as a solution in 25 mM Tris-HCl, pH 8.0, 130 mM NaCl, 0.05% Tween-20, 10% glycerol
Physical properties: Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa
Unit Definition: One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg C