CAS Number: 80295-58-5
MDL No.: MFCD00130847
Purity: >=85% (SDS-PAGE)
Storage: -70C
UNSPSC Code: 12352202
Application: Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). In the (MAC), C8 initiates and coordinates MAC pore formation. It has been used in research to investigate the mechanisms of how C8-C9 and C9-C9 interactions facilitate folding of the membrane attack complex perforin (MACPF) domain to form the circular pore.
Biochem/physiol Actions: C8 is one of the components of the terminal complement complex and is required for a functional complement system. It is composed of disulfide-linked C8alpha and C8gamma and a noncovalently associated C8beta chain. During formation of the membrane-attack complex, a domain on C8alpha induces C9 to polymerize and form a pore-like structure.
Quality: Functionally pure by a sensitive hemolytic assay using depleted sera.
Other Notes: View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
RIDADR: NONH for all modes of transport
WGK Germany: 3