Complement C7 deficient serum human, for complement assays

Storage: -70C

UNSPSC Code: 12352202

Application: Complement C7 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). C7 deficiencies in patients with meningococcal meningitis have shown a mutation which results in an 11 bp deletion in exon 6 resulting in a premature stop codon. Additionally, research has suggested that screening of patients with systemic neisserial infection by CH50 or the APH-50 assay can reveal a C7 deficiency.

Physical form: Supplied as a solution in PBS, pH 7.4

Analysis Note: C7 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.