Synonyms: CTLA4/Fc Chimera, cytolytic
MDL No.: MFCD01092888
Purity: >=99% (SDS-PAGE)
Storage: -20C
UNSPSC Code: 12352200
General description: The complement (C1q) and FcgammaR I binding sites of the Fcgamma2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
Biochem/physiol Actions: CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
Physical form: Solution, 0.2 mum filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
Preparation Note: Purified from serum-free tissue culture supernatant
Other Notes: The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
RIDADR: NONH for all modes of transport
WGK Germany: 3