Synonyms: Carboxylesterase 2 human; CES2; CES2A1
Storage: -70C
Enzyme Commission (EC) Number: 3.1.1.1 ( BRENDA | IUBMB )
UNSPSC Code: 12352204
General description: Carboxylesterase belongs to the +¦/+¦ hydrolase fold family and is involved in drug metabolism and activation. It is present in colon, liver, small intestine, heart, brain and testis. The hydrolase activity of small intestine is attributed to carboxylesterase 2 human. It has two glycosylation sites at 103 and 267 residues with molecular mass 60kDa.
Application: Carboxylesterase 2 may play a key role in biotransformation of a variety of ester containing drugs and prodrugs.
Biochem/physiol Actions: Carboxylesterase 2 human identifies the site containing a large alcohol and small acyl group. It shows less transesterification activity due to presence of conformational interference in active site.
Biochem/physiol Actions: Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.
RIDADR: NONH for all modes of transport
WGK Germany: 2