Synonyms: Carboxylesterase 1 human; carboxylesterase; esterase
Activity: activity: >=1000 units/mg protein
Storage: -70C
Enzyme Commission (EC) Number: 3.1.1.1 ( BRENDA | IUBMB )
EC Number: 232-773-7
UNSPSC Code: 12352204
General description: Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Application: Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic studies for evaluating pro-drugs and non-CYP pathways of elimination.
Physical properties: This product is offered in a volume of 0.5 mL.
Unit Definition: One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 C.
RIDADR: NONH for all modes of transport
WGK Germany: 1