Synonym(s): 1,3,5-Estratriene-3,17β-diol; 17β-Estradiol; 3,17β-Dihydroxy-1,3,5(10)-estratriene; Dihydrofolliculin
Formula: C18H24O2
Formula Weight: 272.38
CAS No.: 50-28-2
Purity: ≥98%
Application: β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).
Physical form: powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Beilstein Registry Number: 1914275
EC No.: 200-023-8
Melting Point: 176-180°C(lit.)
Biochem/physiol Actions: The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
Reconstitution: To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
Empirical Formula (Hill Notation): C6H14N2