Storage: -20C
UNSPSC Code: 12352203
General description: The P2X3 (purinergic receptor P2X 3) receptor is expressed in primary afferent neurons. It is a subtype of P2X receptors family of ligand-gated ion channels, activated by extracellular ATP (adenosine triphosphate).
Application: Anti-Purinergic Receptor P2X3 antibody has been used in immunohistochemistry.
Biochem/physiol Actions: The P2X3 (purinergic receptor P2X 3) plays a major role in the transmission of pain. Inducing P2X3 generates a desensitizing transient response and initiating P2X2/3 creates a relatively persistent response. P2X3 decreases the sympathetic tone in SH rats.
Immunogen: peptide (C)VEKQSTDSGAYSIGH corresponding to residues 383-397 of rat P2rx3.
Physical form: Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
Reconstitution: Reconstitute the lyophilized vial with 50 muL or 200 muL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).
Target description: The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals. Involvement of ATP in the mechanism of chronic pain contributes to P2X3 receptor as a possible target for the development of pain therapeutics.
RIDADR: NONH for all modes of transport
WGK Germany: 2