MDL No.: MFCD00162779
Storage: -20C
UNSPSC Code: 12352203
General description: Reacts against Pseudomonas exotoxin A, but shows no reaction against Staphylococcal enterotoxin A, Cholera toxin, and Staphylococcal enterotoxin B. The product has not been tested for neutralization potency against active Pseudomonas exotoxin A.
Biochem/physiol Actions: Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa and has potent cytotoxic effects. Exotoxin A enters the cells by receptor-mediated endocytosis, translocates to the cytoplasm and inhibits protein synthesis by ADP-ribosylating factor 2. Chimeric exotoxin A has applications in gene treatment of various diseases and probable treatment for cancer.
Immunogen: exotoxin A from Pseudomonas aeruginosa.
RIDADR: NONH for all modes of transport
WGK Germany: nwg