Synonyms: Anti-Aggrus; Anti-GP36; Anti-Glycoprotein, 36-KD; Anti-OTS8; Anti-T1alpha gene; Anti-T1A; Anti-T1A2
MDL No.: MFCD09265367
Storage: -20C
UNSPSC Code: 12352203
General description: Podoplanin (PDPN) is a transmembrane sialoglycoprotein. It consists of 162 amino acids and is part of the type-1 transmembrane sialomucin-like glycoprotein family. The protein is expressed in various tissues. The PDPN gene is localized on human chromosome 1p36.21.
Application: Anti-Podoplanin antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions: Podoplanin (PDPN) is expressed in many cancers. In cancerous cells, it induces platelet aggregation and epithelial-mesenchymal transition. The protein is an immunohistochemical marker of lymphatic vessels. Podoplanin also has a role in embryonic development.
Immunogen: synthetic peptide corresponding to amino acids 24-40 of human podoplanin with an N-terminal added cysteine, conjugated to KLH.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide and 1% bovine serum albumin.
RIDADR: NONH for all modes of transport
WGK Germany: 3