MDL No.: MFCD02097164
Storage: -20C
UNSPSC Code: 12352203
General description: p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.
Biochem/physiol Actions: Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.
Immunogen: synthetic peptide corresponding to residues around Ser392 of human p53 conjugated to KLH.
Physical form: Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 mug/ml bovine serum albumin and 50% glycerol
Specificity: Does not react with non-phosphorylated p53.
Preparation Note: Purified using protein A and peptide affinity chromatography.