Anti-Phosphatidylserine Receptor antibody produced in rabbit, 1-1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyms: Anti-PSR

MDL No.: MFCD04040521

Storage: -20C

UNSPSC Code: 12352203

General description: Phosphatidylserine Receptor (PSR) has been reported and shown to recognize phosphatidylserine in a stereospecific manner. PSR is an evolutionarily conserved glycoprotein that is widely expressed in cells and tissues. It is very susceptible to cleavage by protease or elastase. PSR engagement plays an important role in macro-pinocytosis and uptake of tethered apoptotic cells. Cooperation with other receptors and their ligands may also be needed for ingestion of apoptotic cells. PSR is involved in suppression of inflammatory and immune responses.

Application: Anti-Phosphatidylserine Receptor antibody is sutiable for use in immunoprecipitation and immunoblotting (~50-70 kDa) applications.

Immunogen: synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor conjugated to maleimide-activated KLH. The corresponding sequence in mouse differs by one amino acid.

Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mm sodium azide.

Specificity: Anti-Phosphatidylserine Receptor (PSR) recognizes human and mouse phosphatidylserine receptor (PSR). Detection of the phosphatidylserine receptor by immunoblotting is specifically inhibited by the immunizing peptide, a synthetic peptide corresponding to amino acid residues 363-381 of the human phosphatidylserine receptor, conjugated to maleimide-activated KLH as immunogen.