Synonyms: Anti-Kip2
MDL No.: MFCD01633561
Storage: -20C
UNSPSC Code: 12352203
General description: Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) is a tumor suppressor gene. It is a 316 amino acid protein with conserved amino- and carboxy-terminal domains and sequences with proline-alanine repeats. During mouse embryogenesis, p57KIP2 transcript is highly expressed in skeletal muscles, brain, heart, lungs and eye. The gene encoding this protein is localized on human chromosome 11p15.4.
Application: Anti-p57Kip2 antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions: Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) plays a vital role as a tight-binding inhibitor of several G1 cyclin/cyclin-dependent kinase (CDK) complexes. It is a negative regulator of cell proliferation. Mutation in this gene has been associated with Beckwith-Wiedemann syndrome. p57Kip2 facilitates direct inhibition of DNA replication by binding to the proliferating cell nuclear antigen.
Immunogen: synthetic peptide corresponding to amino acids 303-316 of human Kip2, conjugated to KLH.
Physical form: Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl, and 0.05% sodium azide.
Preparation Note: Purified using protein A
RIDADR: NONH for all modes of transport