Synonyms: Lysyl Oxidase Antibody; Lysyl Oxidase Antibody - Anti-Lysyl Oxidase antibody produced in rabbit; Anti-LOX; Anti-Protein lysine 6-oxidase
Storage: -20C
UNSPSC Code: 12352203
General description: The gene LOX (lysyl oxidase) encodes a copper-dependent amine oxidase that belongs to LOX family of proteins. These proteins contain highly conserved C- terminal mature catalytic domains that include the copper binding site, the lysyl tyrosyl quinine (LTQ) cofactor residues, and the cytokine receptor like (CRL) domain. It is present in both intercellular and intracellular locations.
General description: Rabbit polyclonal anti-Lysyl Oxidase antibody specifically recognizes human lysyl oxidase (LOX). Detection of the LOX band by immunoblotting is specifically inhibited by the LOX immunizing peptide.
Application: Rabbit polyclonal anti-lysyl oxidase antibody is used to tag lysyl oxidase for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting. It is used as a probe to determine the presence and roles of lysyl oxidase in the regulation of collagen and elastin cross-linking and connective tissue remodeling and disorders.
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)
Biochem/physiol Actions: The gene LOX (lysyl oxidase) encodes an extracellular matrix remodeling enzyme that catalyzes the oxidation of primary amino group of peptidyl lysine to reactive peptidyl aldehydes. It is mainly involved in the oxidation of lysine residues in elastin and collagen, resulting in the formation of covalent cross-linkages, which stabilize these fibrous proteins. It also plays a role in several cellular processes such as developmental regulation, tumor suppression, cell motility, and cellular senescence. It is involved in hypoxia-induced metastasis and serves as a therapeutic target for the treatment of metastases.
Immunogen: synthetic peptide corresponding to amino acids 187-202 of human lysyl oxidase (LOX), conjugated to KLH. The corresponding sequence is highly conserved (87% identity) in mouse LOX and (81% identity) in rat LOX.
Physical form: Solution in 0.01 M phosÂphate buffered saline, pH 7.4, containing 15 mM sodium azide.
RIDADR: NONH for all modes of transport