Anti-LXRalpha (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyms: Anti-LX receptor, alpha; Anti-LXR-a; Anti-LXRA; Anti-Liver X receptor a; Anti-NR1H3, nuclear receptor subfamily 1 group H, member 3; Anti-RLD-1

Storage: -20C

UNSPSC Code: 12352203

General description: The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.

Application: Anti-LXRα (N-terminal) antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions: The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.

Immunogen: synthetic peptide corresponding to amino acids 18-35 of human LXRalpha, conjugated to KLH. The corresponding sequence has low homology (58% identity) to rat and mouse LXRalpha.

Physical form: Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.