The gene LC3, also referred to as MAP1LC3A (microtubule associated protein 1 light chain 3 α), is a homologue of Apg8p necessary for autophagy in yeast. The cytosolic form upon processing gets localized to the autophagosome membranes. The gene is mapped to human chromosome 20q11.22. LC3 exists in cells as cytoplasmic LC3-I (18kDa) and LC3-II (16kDa).
Synonyms: Anti-Lc3; LC3 Antibody - Anti-LC3 antibody produced in rabbit; Lc3 Antibody; Anti-MAP1 light chain 3-like protein 1; Anti-MAP1A/1B light chain 3A; Anti-MAP1A/1BLC3; Anti-MAP1A/MAP1B LC3A; Anti-MAP1ALC3; Anti-MAP1BLC3; Anti-MAP1LC3A; Anti-MAP1LC3B; Anti-Microtubule-associated protein 1 light chain 3 alpha; Anti-Microtubule-associated protein 1 light chain 3 beta; Anti-Microtubule-associated proteins 1A/1B light chain 3
Storage: -20C
Application: Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunofluorescence (3 papers)Immunohistochemistry (1 paper)Western Blotting (21 paper)
Biochem Physiol Actions: The gene MAP1LC3A (microtubule associated protein 1 light chain 3 α) encodes a protein that serves as a marker of autophagosomes. It is found to be expressed on surviving oligodendrocytes in Nasu-Hakola disease brains and may be involved in the induction of oligodendrogliopathy.