Anti-LAMP1-Cy3(TM) antibody produced in rabbit, 1-2 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyms: Anti-CD107a; Anti-LAMPA; Anti-LGP120; Anti-Lysosomal-associated membrane protein 1

MDL No.: MFCD01864611

Storage: 2-8C

UNSPSC Code: 12352203

General description: The gene LAMP1 (lysosomal-associated membrane protein 1) encodes a type I transmembrane protein that has a short cytoplasmic tail containing a lysosome-targeting signal of GYQTI(382)-COOH. The gene is mapped to human chromosome 13q34.

Application: Anti-LAMP1-Cy3(TM) antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions: The gene LAMP1 (lysosomal associated membrane protein 1) encodes a membrane glycoprotein that functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. Lamp1 is crucial for perforin trafficking to the lytic granules and motility of these lytic granules. Its knockdown leads to inhibition of cytotoxicity of human natural killer cells.

Immunogen: synthetic peptide corresponding to amino acid residues 405-416 of human LAMP1 conjugated to KLH. The corresponding sequence is identical in rat and mouse.

Physical form: Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.