The gene LAMP1 (lysosomal-associated membrane protein 1) encodes a type I transmembrane protein that has a short cytoplasmic tail containing a lysosome-targeting signal of GYQTI(382)-COOH. The gene is mapped to human chromosome 13q34.
Synonyms: LAMP1 Antibody - Anti-LAMP1 antibody produced in rabbit; Lamp1 Antibody; Anti-CD107a; Anti-LAMPA; Anti-LGP120; Anti-Lysosomal-associated membrane protein 1
MDL Number: MFCD01864611
Storage: -20C
Application: Anti-LAMP1-Cy3(R) antibody produced in rabbit has been used in western blotting and immunofluorescence.
Biochem Physiol Actions: The gene LAMP1 (lysosomal associated membrane protein 1) encodes a membrane glycoprotein that functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. Lamp1 is crucial for perforin trafficking to the lytic granules and motility of these lytic granules. Its knockdown leads to inhibition of cytotoxicity of human natural killer cells.
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