MDL No.: MFCD03455360
Storage: -20C
UNSPSC Code: 12352203
General description: Afadin is a multidomain protein that binds F-actin and E-catenin proteins at cell-cell adheren junctions. I-afadin is a ubiquitously expressed splice variant of afadin that contains PDZ and F-actin binding domains at the C-terminal end. I-afadin is homologous to the human AF-6 protein , . AF-6/Afadin regulates the formation of tight and adherens junctions in the cell and its absence in mice leads to embryonic defects and lethality , Anti-l-Afadin antibody is specific for I-afadin (approximately 200 kDa). It also binds I-afadin in rat, mouse, dog and human.
Application: Rabbit anti-l-afadin antibody may be used for immunocytochemistry on DLD1 cells, immunoblotting and also for immunohistochemistry .
Application: Rabbit anti-l-afadin antibody is also suitable for use in microarray and indirect immunofluorescence assays.
Immunogen: Synthetic peptide sequence corresponding to amino acid residues 1814-1829 of rat afadin with N-terminal cysteine conjugated to maleimide-activated KLH.
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide
RIDADR: NONH for all modes of transport
WGK Germany: 2